Çukurova Pharmaceutical
Doksinova 50

Powder for use in drinking water
Veterinary Systemic Antibacterial

The Composition
Doksinova 50 contains 500 mg doxycycline in 1 gram.

Pharmacological Properties

Doxycycline is a semisynthetic tetracycline derivative. It acts by inhibiting protein synthesis at the ribosomal level, predominantly by binding to the 30S ribosomal subunits of bacteria. Doxycycline is a broad-spectrum antibiotic. It exhibits a wide range of activity against gram-positive aerobic pathogens (Bacillus sp., Corynebacterium sp., Erysipelothrix rhusiopathia, Listeria monocytogenes and Streptococci.) and gram-negative bacteries (Actinobacillus sp., Bordetella sp., Francisella tularensis, Haemophilus sp., Pasteurella multocida, P. haemolytica, Yersinia sp., Campylobacter fetus, Borrelia sp. ve Leptospira sp. Moraxella bovis), anaerobic pathogens (Actinomyces sp., Fusobacterium sp.) and Mycoplasma sp., Chlamydia sp., Ehrlichia sp., Coxiella burnetti, Ehrlichia, Eperythrozoon and Anaplasma in chickens and turkeys.

The resistance rate of Mycobacterium sp., Proteus vulgaris, Pseudomonas aeroginosa, Serratia sp., Mycoplasma bovis and M. hyopneumoniae isolates against doxycycline is low.

Doxycycline acts on the subunit 30 S of the bacterial ribosome, to which is bound reversibly, blocking the union between aminoacyl-tRNA(transfer RNA) to the mRNA-ribosome complex, preventing the addition of new aminoacids into the growing peptide chain an thus interfering with protein synthesis. In general, doxycycline is quite rapidly and extensively absorbed from the gastrointestinal tract, widely distributed in the organism, not metabolised to any significant extent and excreted mostly via the faeces. Pharmacokinetics of doxycycline after single oral administration to chickens and turkeys is characterised by a quite rapid and substantial absorption from the gastrointestinal tract providing peak plasma concentrations between 0.4 and 3.3 hours in chickens and 1.5 to 7.5 hours in turkeys depending on age and the presence of food. The drug is widely distributed in the organism with Vd values close to or greater than 1, and exhibits shorter elimination half-life in chickens (4.8 to 9.4 hours) than in turkeys (7.9 to 10.8 hours). The protein binding ratio at therapeutic plasma concentrations is in the range of 70-85%. The bioavailability in chickens and turkeys may vary between 41 and 73%, and 25 and 64%, respectively also depending on the age and feeding. The presence of food in the gastrointestinal tract determines a lower bioavailability compared to that obtained in the fasted state.

Chickens and turkeys: Cholera, coryza, diarrhea of bacterial origin and treatment of clinical respiratory infections associated with Mycoplasma gallisepticum susceptible to doxycycline.

Administration and Dosage
If not otherwise recommended by veterinarians; 20.0 mg doxycycline per kg of body weight daily (equivalent to 40.0 mg product per kg of body weight), administered in the drinking water for 5 consecutive days.
Total average body weight
(Chicken and Turkey)
Amount of Doksinova 50
1000 kg 40 g
10.000 kg 400 g
25.000 kg 1 kg
50.000 kg 2 kg

Drug Withdrawal Period Of Residual
Meat and offal of chickens: 4 days.
Meat and offal of turkeys: 6 days.
Not permitted for use in laying birds producing eggs for human consumption.

Type of Packaging
100 g, 500 g, 1 kg, 1,5 kg and 2,5 kg round pet container are presented for sale as unboxed.
This part of website targets just for veterinarians. Please confirm your profession as a veterinarian by clicking "Yes" button.
Other wise please select "No" button and continue navigation other parts of website.