Çukurova Pharmaceutical

Oral Suspension
Veterinary Systemic Antibacterial

The Composition

Trimetova Oral Suspension is clear, honey colored suspension and provides 400 mg Sulfadiazine, 80 mg Trimethoprim in 1 ml.

Pharmacological Properties

Sulfamide group diaminoprimidin group with sulfadiazine prepared on the basis of the combination of trimethoprim, reinforced with a combination of a sulfonamide Trimetrova Oral Suspension for oral administration, effective against gram-negative and gram-positive bacteria; domestic pets digestive, respiratory, urogenital and systemic infections used; broad spectrum, light characteristic odor, light-colored suspension of antibiotics.

Sulfadiazine and trimethoprim in Trimetova are synergistic effective. This synergistic effect inhibits the synthesis of folic acid in two steps by forming consecutive qualified blockage for tetrahydrofolic acid synthesis in bacteria enzyme systems tasked and provides irreversibly a bactericidal effect. Trimethprim inhibits the dihydropteroate reductase enzyme in the synthesis of folic acid bacteria. Furthermore, sulfadiazine eliminates competitively PABA which is vital for bacteria, connects dihydropteroate synthetase enzyme and blocks the dihidrofolik acid synthesis. Stronger antibacterial activity with a synergistic effect that results from the combination of sulfadiazine and trimethoprim, development of resistance to a wide spectrum and reduction in the risk of pathogenic bacteria, is invisible when the same active ingredients are not used individually.

Mainly sensitive bacteria of trimethoprim+sulfadiazine combinations:

  • Gram positive aerobes: Staphylococcus Aureus, Streptococcus sp., Actinomyces sp., Corynebacterium sp, Listeria monocytogenes., Erysipelothrix rhusiopathie.
  • Gram negative aerobes: Enterobacteriaceae (E.coli, Klebsiella sp, Proteus sp, Salmonella spp., Yersinia spp., ) Actinobacillus sp, Bordetella spp., Haemophilus spp., Pasteurella spp.
  • Anaerobes: Actinomyces spp., Bacteroides spp., Fusobacterium spp., bazı Clostridium spp.,Chlamydia spp.,
  • Moderately susceptible bacteria: some Mycobacterium spp., some Nocardia spp

Ricketsia spp., Leptospira spp., Pseudomonas aeroginosa, Mycoplasma spp. are considered to be resistant.

Sulfadiazine and trimethoprim, is rapidly absorbed following oral administration with high plasma concentrations of the appropriate synergistic ratio of about 1:20, protects for 12 hours. Sulfadiazine and trimethoprim in poultry gut absorbed following oral administration is approximately 40-45 minutes in the highest drug concentrations reach 2-2.5 hours. After Sulfadiazine and trimetroprim are absorbed intestinal tissue; instrasellüler extra and liquids, scrobrospinal fluid, fetus, milk, sekrasyonları digestive tract, bile, segments, including high concentrations of textural dissolved. Plasma half-life is approximately 6.5-7 hours.

The majority of sulfadiazine and trimethoprim is excreted in the urine through the kidneys without any metabolic changes.

Trimetova Oral Suspension used for treatment of infections caused by susceptible bacteria in foals, broiler chickens and turkeys with not begun rumination the lambs, calves and kids. In this context, Pullorum, chicken typhoid, chicken cholera, Pasteurellosis, Air bladder infections, infections caused by E.Coli, infections effected by sensitive bacteria and associated Salpingitis with viral infections in chichen and turkeys; infections by caused gastroenteritis, diphtheria Colibacillosis, Colisepticemia in calves, lambs and kids.

Administration and Dosage

If not otherwise recommended by veterinarians;

The dose of drug to be administered is 15 to 30 mg / kg body weight / day. For broiler chickens, considering the age and the type of the animal, 1-2 ml doses of 5 L of drinking water for 3-5 days Trimetova Oral Suspension is continued by adding the application. In collective applications, Trimetova Oral Suspension should be applied 15 to 30 ml / day for 450 kg of live weight in drinking water of animals.

Lambs, calves, kids and foals: Trimetova Oral Suspension is given 1 ml/15kg body weight /day for 5 days by mixed with drinking water or milk . In severe infections, the recommended therapeutic dose is removed from 2 times.

Medicament should be prepared fresh every day.

Type of Packaging
200 ml amber glass bottle, boxed, 500 ml, 1000 ml and 3000 ml white in color and the key-cap plastic containers are presented to sold as unboxed.

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