Çukurova Pharmaceutical

Heksamizol

Veterinary Anthelmintic

Off white - cream-colored, middle notched, oval Heksamizol each tablet: Cointains 500 mg Triclabendazole and 441 mg Levamisole HCl that the equivalent of 350 mg Levamisole.

Heksamizol Oral Tablet is combination of broad-spectrum anthelmintic that is used against with butterflies of liver, gastroinstestinal nematodes and lung bristle worms in cattles and sheeps.

Triclabendazole is a derivative of benzimidazole antihelmintic, in cattle and sheep fascioliasis causing antitrematodal effect on young and adult forms of Fasciola hepatica and Fasciola gigantica. It is effective in preventing activity of Fumarate reductase the parasites. Triclabendazole is absorbed from the gastrointestinal tract after oral administration, between 8-24 hours depending on the occupancy of the digestive tract reaches peak plasma density and is distributed throughout the entire body. It is translated derivatives of sulfone and sulfoxide in body and concentrated mainly in the liver and thyroid gland. Almost all of the dose given at the end of the 10th day following the treatment, is excreted largely in stool and a small amount in the urine. In very rare cases, the eggs of Fasciola species can be seen in resistance to Triclabendazole.

Levamisol is an antihelmintic of imidazo azole derivative which especially is effective to nematodes in gastrointestinal and lungs. Similar to the effect of pirantel, as a result of continuous stimulation of muscles and ganglia helminths along with the stroke, fumarate reductase activity is based on prevention.

Levamisole HCl is rapidly absorbed from the gastrointestinal tract after oral administration in 1-2 hours, is reached the peak plasma concentration, and distributed to all body parts. It suffers greatly to biotransformation in the body. Plasma half-life is 4-6 hours. It is excreted largely in stool and a small amount in the urine.

Heksamizol Oral Tablet, cattle and sheep, is used to teh treatment and the struggle of the following nematode invasion, especially acute Fascioliasis:

Liver Trematods: (1-13 Weekly, including larvae), F. hepatica and F. Gigantica

Gastrointestinal Bristle Worms: (Haemonchus sp., Oestertagia sp., Trichostrangylus sp., Cooperia sp., Nematodirus sp., Bunostomum sp., Chabertia sp., and Oesophagostomum sp.

Lung Bristle Worms: Dictyocaulus viviparus, Lavral and adult forms of D. Filaria.

If not otherwise recommended by veterinarians;

Pharmacological doses: 10 mg/kg c.a. Triclabendazole and 7,5 mg/kg c.a. Levamisole

Practical doses: 1 tablet for 50 kg body weight

Sheep		Cattle
Body Weight (Kg)	Tablet	Body Weight (Kg)	Tablet
25	1/2	50	1
35	3/4	100	2
50	1	150	3
For every 25 kg of body weight, 1/2 of the tablet is given to over 50 kg of the sheeps.		200	4
		300	6
		400	8
		500	10

Tablets can be used swallowing or drinking dissolved in water.

During treatment and after the last drug use, cattles and sheeps raised for meat must not be sent slaughtering for 28 days. Dairy milk for human consumption for cattles and sheeps must not be applied .

Covered with aluminum foil blister packs of 10, 50 and 100 tablets is presented in a cardboard box.