Çukurova Pharmaceutical

Iveroxin

Veterinary Endectocides

Ivermectin is a 22,23-dihydro derivative of an avermectin (which is a fermentation product produced by Streptomyces avermitilis) and consists of 2 homologues: B1a and B1b. It is a parasiticide with nematocidal, insecticidal and acaricidal activity documented in a wide range of domesticated animals. Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of this class bind selectively and with high affinity to glutamate gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with the hyper-polarisation of the nerve or muscle cell resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate gated chloride channels, the macrocyclic lactone have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.

In cattles, at a dose level of 0.2 mg ivermectin per kg a maximum plasma concentration of 35-50 ng/ml is reached in +/- 2 days and the half-life in plasma is 2.8 days. It is also established that ivermectin is carried mainly in the plasma (80%). This distribution between plasma and blood cells remain relatively constant. In sheeps, at a dose level of 0.3 mg ivermectin per kg an average peak of 16 ng/ml is reached one day after injection. Analyses of the faeces showed that about 99% of the drug and its metabolites are excreted in the faeces, +/- 1 % being excreted in the urine.

IVEROXIN Injection for Cattle and Sheep is indicated for the effective treatment and control of the following harmful parasites of cattle and sheep:

Cattle

Cattle

İVEROXİN Solution for injection should be given only by subcutaneous injection at the recommended dosage level of 200 mcg ivermectin per kg bodyweight under the loose skin in front of, or behind, the shoulder in cattle and in the neck in sheep. Syringes must be filled from the vial through a dry sterile draw-off needle that has been placed in the vial stopper. Vial stoppers must not be broached more than 20 times.

This product does not contain an antimicrobial preservative. Swab septum before removing each dose. Use sterile needle and syringe. When treating groups of animals use only an automatic dosing device (with vented draw-off apparatus when using the 50ml vial). To ensure administration of a correct dose, body weight should be determined as accurately as possible; accuracy of the dosing device should be checked.

Use this chart as a guide in working out the appropriate dose rate:

10 ml. den daha fazla hacimdeki dozların bölünerek ayrı yerlere enjekte edilmesi tavsiye olunur. Sadece deri altı enjeksiyona mahsustur. Kas içi ve damar içi yolla kullanmayınız.

Cattle (meat & Offal): 42 days
Sheep (meat & offal): 35 days

Do not use in cattle and sheep producing milk for human consumption.