Çukurova Pharmaceutical

Oksamizol

Veterinary Anthelmintic

Oksamizol Oral Tablet is broad-spectrum anthelmintic with prepared a balanced combination of two active substances.

Oxyclozanide is an anthelmintic of the salicylanilide group. It is effective against Fasciola species, acting as an uncoupler of oxidative phosphorylation. It may act at more than one site to decrease levels of ATP leading to metabolic malfunction and death of the parasite. Oxyclozanide is slowly absorbed after oral administration with peak plasma levels 45 hours after dosing. Excretion is predominantly faecal, biliary excretion being the most important route of elimination.

Oxfendazole, one of the benzimidazole group of compounds with anthelmintic activity. Benzimidazoles bind to nematode tubulin, a protein necessary for the formation and viability of microtubules, primarily in the absorptive intestinal cells of the nematode. This results in a complete absence of microtubules in the intestinal cells leading to a reduction in the absorption of nutrients, a reduction in glycogen and the effective starvation of the parasite. Oxfendazole is slowly and incompletely absorbed after oral administration, with Cmax reached between 15 and 30 hours, followed by slow elimination. This slow rate of absorption and elimination means that the drug is in contact with the helminths for significantly long periods of time. Oxfendazole has four main metabolites fenbendazole, fenbendazole sulphone, p-hydroxy fenbendazole and fenbendazole amine. While oxfendazole and fenbendazole are anthelmintically active, the other metabolites have minimal or no anthelmintic activity.

Oksamizol Oral Tablet, cattle and sheep, is used to teh treatment and the struggle of the following nematode invasion, especially Moniezia spp:

Liver Trematods: F. hepatica and F. Gigantica

Gastrointestinal Bristle Worms: Haemonchus sp., Oestertagia sp., Trichostrangylus sp., Cooperia sp., Nematodirus sp., Bunostomum sp., Chabertia sp., Oesophagostomum sp. Trichuris sp, T.colubriformis, Trichostrongylus sp, Gaigeria pachyscelis

Lung Bristle Worms: Dictyocaulus spp

Cestoides: Moniesia sp.

If not otherwise recommended by veterinarians;

Pharmacological doses:
Sheep: 5-7,5 mg/kg b.w. Oxfendazole and 15-20 mg/kg Oxyclozanide
Cattle: 5mg/kg b.w. Oxfendazole and 10-15mg/kg Oxyclozanide

Practical doses:
Lamb (20 kg) :1/2 tablet
Sheep (40 kg) : 1 tablet
Calf (100-200) : 2-3 tablet
Cattle (200-300) : 3-4 tablet

Oksamizol Oral Tablet can be used swallowing or drinking dissolved in water.

During treatment and after the last drug use, cattles raised for meat must not be sent slaughtering for 28 days and sheeps raised for meat must not be sent slaughtering for 21 days. Dairy milk for human consumption of cows must not be applied for 5 days.

Not for use in sheep producing milk for human consumption.