Çukurova Pharmaceutical

Oral Solution
Veterinary Systemic Antibacterial

The Composition

Roxanova Oral Solution is 1 ml solution containing 100 mg Enrofloxacin base, light yellow, clear solution.

Pharmacological Properties

Enrofloxacin is a broad-spectrum antibacterial that belong to group of fluoroquinolones. It is given bactericidal effect by blocking the activity of the enzyme of Bacterial DNA-jiraz.

The main bacterias susceptible to Enrofloxasin: E.coli, Salmonella sp., Enterobacter sp., Serratia sp., Proteus sp., Klebsiella sp., Shigella sp., Yersinia sp., Moraxella sp., Acinobacter sp., Actinobacillus sp., Pasteurella sp., Leptospira sp., Campylobacter sp., Citrobacter sp., Haemophilus sp., Ehrlichia sp., Coxiella brunetti, including those resistant to methicillin and gentamicin Staphylococcus sp., including those in the penicillin-resistant N.gonorrhoeae, N. meningiditis, Corynebacterium sp., Chlamydia sp., V.cholerae, Mycoplasma sp.

Strep, suis, Strep, agalactia, Strep dysgalactia, Strep, zooepidemicus, R.equi, Mycobacterium sp. are shown moderate sensitivity.

Most of the anaerobic cocci, Clostridium sp., Bacteroides sp., ve Ps. maltophila kinolon are typically less susceptible or resistant.

Enrofloxacin is absorbed more than 60% from the gastrointestinal tract in poultry. It is reached 2.44 jıg/ml 1.64 per hour the peak plasma concentration when given 10 mg / kg dose in poultry and usually 0.5 pg / ML during 12 hours remains at a level above. The pharmaceuticals in circulation are generally connected to plasma proteins lower ratio. Repeated drug is given, tends to accumulate in the serum. Enrofloxacin distributes to all body tissues; especcially located in high concentrations in the bile, the liver, lungs and kidneys. Its lung density may be many doubled than plasma density. The volume of distribution is extremely large; Vd of chichen is 4,3 L/kg. Drug in the body, including ciprofloxacin is converted many effective-ineffective metabolites; up to 10-50% in unchanged form excreted in urine and bile. The excretion half-life is 10 hours in chichens, 4-6 hours in turkeys.

Roxanova Oral Solution is used for infections that caused by sensetive bacteria to enrofloxacin in broiler chickens. In this context, it is indicated Mycoplasmosis (CRD-Chronic Respiratory Disease), Colibacillosis, Salmonellosis, Pasteurellosis, Staphylococcosis infections.

Administration and Dosage

If not otherwise recommended by veterinarians;

Broiler chickens, the drug is applied 10 mg / kg body weight / day dose into account that drinking water. Although it varies that depending on water consumption, Roxanova Oral Solution is attended 100 ml of 200 liters of drinking water for every 1000 kg of live weight.

Treatment should be continued for 3-5 days. It is recommended 5-10 days to types of infections caused by Salmonella and Pasteurella. Medicated drinking water should be prepared and used on a daily basis. Before the application, drinking water must be clean and not carry the acid character. Enrofloxacin solution is more stable in alkaline media, so application should be done with clean drinking water and the animals are thirsty since evening. The drug is given within 2 hours in drinking water.

Drug Withdrawal Period Of Residual
During treatment and after the last treatment, chickens raised for meat should not send for slaughtering 12 days.

Type of Packaging
100 ml white plastic bottle in a cardboard box, 500 - 1000 and 3000 ml white plastic bottles are presented for sale as unboxed.

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